There’s a process to it and it’s working. See how Technome applies decades of domain knowledge and solid project management to achieve these results.
Answer ALS
Case Study
AMP PD
Case Study
AMP PD
Overview
Overview: The Accelerating Medicines Partnership: Parkinson’s Disease (AMP PD) is a public-private partnership aimed at identifying and validating the most promising biological targets for therapeutics. AMP PD brings together experts with different perspectives to achieve a common goal. AMP PD partners, including experts from biopharmaceutical companies, non-profit organizations, and academic, and government institutions, contribute and share research insights using technology platforms built by Verily, Google, Technome, and the Broad Institute. AMP PD is a hub of resources for the scientific community, focused on molecular characterization of PD patient samples using multiple -omics and longitudinal clinical profiling of patient data. With this extensive partnership, AMP PD is driving the identification and validation of diagnostic, prognostic, and disease progression biomarkers for Parkinson’s Disease.
With extensive experience working in collaborative research projects, Technome joined AMP PD in 2017 to provide technical direction and data coordination. Technome joined forces with Verily to build an infrastructure capable of scaling to support petabytes of sequencing and other types of data, processed derivatives, and analyses that further Parkinson’s research.
With the infrastructure in place, Technome engaged with partners and external collaborators in 2018 to begin accepting and curating genomic and transcriptomic data, along with associated clinical data, culminating in a database of over 10,000 unique participants. Today, Technome manages the Google Cloud Platform infrastructure for AMP PD, including data storage, data processing, and analyses, enabling researchers to perform and share their work in the cloud.
Today, AMP PD presents the largest harmonized data set in Parkinson’s Disease research, curated from 8 separate studies, with new data being added on an ongoing basis. In working with AMP PD, Technome has developed formalized processes and tools that are well-organized and scalable and can be shared and re-used to solve the problems that large research programs face. All data sets and analysis notebooks are managed by Technome and are made available to AMP PD users through Google Cloud and Terra, a platform co-developed by The Broad Institute of Harvard and MIT, Microsoft, and Verily.
Answer ALS
Overview
Answer ALS combines Clinical, Genomics, Epigenomics, Proteomics, and Transcriptomics data for a cohort of over 1000 ALS patients, producing the most extensive dataset in the history of ALS research. This project, aimed at defining molecular mechanisms of a devastating neurodegenerative disease, uses whole blood derived stem cells for all subject participants. Technome is part of the AnswerALS team, which also includes Cedars Sinai Medical Center, University of California, Johns Hopkins University, and MIT.
Answer ALS selected Technome as the Lead Architect in 2017 to manage their cloud infrastructure and provide technical guidance to the Answer ALS board, the program directors, and academic partners.
Technome engaged with key stakeholders to translate their vision into an infrastructure roadmap and a high-level plan for delivery. Executing on this plan, Technome engineers built the Answer ALS cloud framework and data management processes, drawing insight and support from an army of committed technical experts from Microsoft, Avanade, and other key Answer ALS partners.
Technome’s approach is to manage the complexities of infrastructure and data management, to apply practices and data standards from decades of similar successes, and to grow and adapt with the Answer community.
Answer ALS, with help from Technome, Microsoft and other partners, has built a stable, robust, scalable infrastructure and now hosts the largest collection of ALS research data in the world. Technome has worked with Answer ALS to organize their data curation processes, establishing a centralized Data Coordinating Center, which has regularly released consistent and easy to read datasets. Answer ALS has built acclaimed systems and organized datasets that have spurred new interest in the community and forged new partnerships.
In 2021, Technome was challenged by the chairman of the Answer board to engineer the architecture for a new Data Portal in a way that meets today’s budget but allows the Answer community to build upon it in the future. In partnership with OnPoint Scientific and Microsoft’s Accessibility Team, Technome drove the technical solution to build one of the cleanest, most usable Data Portals in Health Sciences research.
Let’s make a difference impossible to ignore.
Together, we can make a lasting mark on the scientific community—and the world. Contact us to discuss how Technome can assist your research project or to ask about joining our fast-growing team.
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